Nebido 1000 mg Bayer | EPC-0249

105.00€
  • Brand:Bayer
  • Product Code:EPC-0249
  • Availability:In Stock
Free delivery from 300 euros. Check amount from 200-299 - 25 euros, Check amount up to 199 euros - delivery cost 45 euros.

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Description Nebido 1000 mg from Bayer

Nebido 1000 mg from Bayer is an intramuscular depot drug containing testosterone undecanoate. For this reason, the effect of the first passage is absent. After intravenous injection of an oil solution of testosterone undecanoate, it is gradually released from the depot and almost completely broken down by serum esterases into testosterone and undecanoic acid.

In two separate studies, the average testosterone Cmax values of 24 and 45 nmol / L were determined, respectively, 14 and 7 days after a single intravenous injection of 1000 mg of testosterone undecanoate to men suffering from hypogonadism. Postmaximal testosterone levels decreased, with T1 / 2 being approximately 53 days.

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Metabolism. Testosterone, which is formed from testosterone undecanoate as a result of the cleavage of the ether bond, is metabolized and excreted from the body in the same ways as endogenous testosterone. Undecanoic acid is metabolized by β-oxidation in the same way as other aliphatic carboxylic acids.

Testosterone undergoes significant metabolism in the liver and beyond. After the introduction of labeled testosterone, about 90% of radioactivity is detected in the urine in the form of glucuronide and sulfate acid conjugates, and 6% after passing the intestinal-hepatic circulation is detected in the feces. Products detected in the urine include androsterone and etiocholanolone.

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Method of administration and dosage Nebido from Bayer in England

Nebido is produced 1 time in 10-14 weeks. With this frequency of injections, sufficient testosterone levels are maintained, and no accumulation of the substance occurs.

The contents of the ampoule or vial should be injected immediately after opening. The injection should be made very slowly. Nebido 1000 mg from Bayer can only be administered strictly in/m. It is necessary to carefully ensure that the injected substance does not enter the vessel.

Start of treatment. Before starting treatment, you should determine the amount of testosterone in the blood serum. The first interval between injections can be shortened, but it should be at least 6 weeks. Css at this dose is achieved quickly.

Individual treatment adjustment. At the end of the interval between injections, it is recommended to measure the concentration of testosterone in the blood serum.

If its concentration is lower than normal, then this may indicate the need to reduce the interval between injections. At high concentrations, it should be considered whether it is appropriate to increase this interval. The interval between injections should remain within the recommended range of 10-14 weeks.

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Contraindications Nebido 1000 mg

  • hypersensitivity to the active substance or to any of the auxiliary components of the drug;
  • the presence of androgen-dependent prostate or breast carcinoma in men;
  • hypercalcemia associated with malignant tumors;
  • liver tumors currently present or in the anamnesis.
  • Nebido should not be used in women.

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Active substance: Testosteron Undecanate, Testosterone
Active ingredient, mg: 1000
Release form: Ampoule
1 bottle, ml: 4
Ampoules per package, pcs: 3
Manufacturer: Bayer
Packing: Ampoule, Packing (5 ampoules)

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