Letrozol, produced by Balkan Pharmaceuticals, is a powerful antiestrogenic drug (aromatase inhibitor by type of action), widely used in sport as a means to prevent the development of estrogenic side effects. It is usually taken during steroid courses in order to block androgen aromatization and thus prevent excessive fluid accumulation, increased pressure, increased body fat and also symptoms of gynecomastia in men.
The active ingredient letrozole (with the same name as the drug) is an inhibitor of estrogen synthesis. Initially, it is an antitumor drug, prescribed primarily for women with cancer. In sports, such as anastrozole, it has spread after the highest antiestrogenic activity / efficacy demonstrated when taken with steroid courses.
Letrozole selectively blocks aromatase (an enzyme of estrogen synthesis) by binding competitively to its subunit (heme of cytochrome P450). It effectively prevents the conversion of androgens into estrogen in the liver, skeletal muscle tissue and adipose tissue, reducing the concentration of female sex hormones in the systemic circulation to 75-95% of initial values.
Letrozole Balkan Pharma (Moldova), if taken within the recommended doses, lowers estradiol, estrone and estrone sulfate, while the suppression of the synthesis of female sex hormones is maintained throughout the period of action. It is important that this antiestrogen does not interrupt the synthesis of natural steroid hormones (corticosteroids) in the adrenal glands, as well as aldosterone or thyroid hormones, so additional use of glucocorticoids and mineralcorticoids is not necessary to compensate, which reduces the risk.
The drug Letrozole, causing the inhibition of estrogen biosynthesis, is able to increase endogenous testosterone levels through feedback (the antiestrogen does not affect the production of the hormone itself). Against the background of drug use, there is no pronounced change in the production of LH and FSH (gonadotropic hormones responsible for regulating testosterone production by the body). It is not a direct testosterone booster such as human chorionic gonadotropin.
Possible side effects of Letrozol Balkan Pharmaceuticals are reactions of the nervous system, reactions of the digestive, hematopoietic or respiratory system, dermatological reactions, reactions of the genito-urinary system, musculoskeletal system and others. Possible side effects include: dizziness and general weakness, nausea and vomiting, shortness of breath, tachycardia, sweating and rashes, feeling hot, frequent urination and some other disorders. It is important to note that with normalized intake of pills, side effects are rare or mild, i.e. they do not interfere with normal life.