Human chorionic gonadotropin (HCG) is a gonadotropin hormone produced by the placenta during pregnancy and then eliminated unchanged by the kidneys. To obtain the drug is extracted from the urine and cleaned. It is necessary for normal growth and maturation of gametes in women and men, as well as for the production of sex hormones.
Has a gonadotropic, folliculostmulating and luteinizing effect. Luteinizing activity prevails over folliculostimulating. Stimulates the development of genital organs and secondary sexual characteristics. In women, the drug causes ovulation and stimulates the synthesis of estrogens (estradiol) and progesterone. In men - stimulates spermatogenesis, the production of testosterone and dihydrotestosterone.Deposition
- induction of ovulation in infertility caused by anovulation or impaired maturation of follicles;
- preparation of follicles for puncture in programs of controlled ovarian hyperstimulation (for assisted reproductive techniques);
- maintain the phase of the yellow body.
- In men:
- hypogonadotropic hypogonadism;
- perform a Leydig functional test to assess testicular function in hypogonadotropic hypogonadism before starting long-term stimulating therapy.Method of administration and dose
After adding the solvent to the lyophilisate, a reduced solution of chorionic gonadotropin is administered intramuscularly. The prepared solution is not stored, since the preservation of the sterility of the solution is not guaranteed. The indicated doses are approximate, the treatment should be adjusted individually by the doctor depending on the reaction necessary for the administration of the drug.
- When induction of ovulation in infertility due to anovulation or impaired maturation of follicles
- Usually an injection of the drug Chorionic Gonadotropin in the dose is administered
- 5,000-10,000 ME to supplement treatment with FSH drugs;
- When preparing follicles or puncture in programs of controlled ovarian stimulation (CSIA)
- Usually, an injection f chorionic gonadotropin in a dose of 5,000-10,000 ME is given to supplement treatment with FSH drugs
- Luteal phase support in women during controlled ovarian stimulation during VRT
- Two to three repeated injections of the drug at a dose of 1,000 ME to 3,000 ME each can be performed within 9 days after ovulation or embryo transfer (for example, 3, 6 and 9 days after induction of ovulation).
The doses listed below are indicative and should be adjusted individually according to the clinical response.
Hypogonadotropic hypogonadism and idiopathic dyspermias
1000-2000 ME medication 2-3 times a week. In case of infertility associated with dispersion, it is possible to combine chorionic Gonadotropin with an additional drug containing follitropin (FSH) 2-3 times a week. Treatment should last at least 3 months, until the expected improvement in spermatogenesis. During this treatment, it is necessary to suspend testosterone replacement therapy. When improvement of spermatogenesis is achieved, it is sufficient, in some cases, an isolated application of HCG to maintain it.
- With the delay of puberty, due to insufficient gonadotropic function of the pituitary gland
- 1500 ME 2-3 times a week. The course of treatment - at least 6 months.
- In cryptorchidism, not caused by anatomical obstruction:
- at the age of 2 years-250 ME is administered twice a week for 6 weeks;
- at the age of 6 years - injected 500-1000 ME twice a week for 6 weeks;
- at more than 6 years - 1500 ME is injected twice a week for 6 weeks. The course of treatment, if necessary, can be repeated.