GHRP-6 is a synthetic version of ghrelin (as GHRP-2) that stimulates the release of endogenous growth hormone (GH) in the somatotropic anterior pituitary gland in animals and humans. This peptide is an excellent alternative to GHRP-2, because it does not cause such a strong increase in appetite (it is, but not so pronounced), at the same time it carries all the benefits of GHRP-2, such as a powerful release of growth hormone, improved heart function, blood lipid profile, muscle growth, normalization of the immune system, regeneration of joints and ligaments, and much more.
Mechanism of action
GHRP-6 will increase the amount of somatotropic hormone by suppressing the level of somatostatin present, whereas standard somatopropin releasing hormone (its synthetic analog CJC-1295) increases the amplitude of GH pulsation in the pituitary gland. Unlike ghrelin, GHRP-6 is not specifically used to increase appetite, but it may have a secondary activity that affects the hypothalamic neurons that cause hunger, but not as intensely as in GHRP-2. These effects continue for about an hour after the initial application, which mimics the natural surge of GH. In studies, GHRP-6 has shown a biological effect similar to the natural mechanism of ghrelin-induced hunger.
Its main purpose is to stimulate the consumption of food, stimulating the feeling of hunger and helping in energy metabolism. It can be used in the treatment of GH deficiency, as well as for cachexia, eating disorders and obesity. GHRP-6 is a synthetic meth-enkephalin (a natural analog of the opioid growth factor). GHRP-6 contains D-amino acids, which are completely synthetic, have no opioid activity, and have no sequence relationship to the somatopropin-releasing hormone. It has also been shown that GHRP-6 can lead to re-stimulation of the natural production of the somatotropic hormone. Studies have shown that GHRP-6 increases the secretion of IGF-1 (the insulin-like growth factor of the first type) by the liver, which is a necessary intermediary in the anabolic mechanisms that lead to the action of growth hormone. GHRP-6 also appears to have a positive effect on the central nervous system, as ghrelin is known to protect neurons. What may be the most interesting aspect of ghrelin (and hence GHRP-6) is the huge variety of roles it plays in the body's biological functions. It is involved in processes that include appetite regulation, heart function, gastrointestinal function, carbohydrate metabolism, and even has some behavioral effects.
- intensive stimulation of GH production and somatomedin;
- increased protein synthesis in the muscles (muscle growth);
- immune system optimization;
- accelerate the burning of fat reserves;
- normalizes the blood lipid profile;
- accelerates the regeneration of ligaments and tendons
GHRP-6 is injected subcutaneously with an insulin syringe into the fold of the skin of the abdomen at a dose of 100 mcg three times a day. In the morning, an hour before a meal, two hours after lunch, or 15 minutes before a workout, just before bedtime.
The product is supplied in powder form, so it must be reconstituted with bacteriostatic water or water for injection. Most often, 2 ml of water is injected through the rubber cap of the bottle with a conventional syringe, the water should slowly flow down the wall of the bottle, without immediately falling into the powder (this will avoid destroying the structure of the peptide). Next, you need to wait until the powder is completely dissolved (it can not be shaken or knocked to prevent the destruction of the amino acid structure of the peptide). Store the product in the refrigerator at a temperature of 2-8 degrees Celsius, do not freeze it and avoid direct sunlight on the bottle.
GHRP-6 in recommended doses, CJC-1295 DAC 1000 mcg twice a week, PEG MGF 200-400 mcg in target muscles after training (no more than 3 times a week), ACE-031 100 mcg per day.
Side effects are similar to GHRP-2 (pain and redness at the injection site), throbbing, dizziness, or a feeling of euphoria within 30 minutes of administration. You can also increase the feeling of hunger.