Safety precautions Before and during treatment, it is necessary to constantly monitor the gynecologist, check the function of the ovaries, perform vaginal examinations, observe the phenomenon of the "pupil" , etc. With an increase in the ovaries or their cystic transformation, treatment with clomiphene is suspended until the size of the ovaries normalizes. Therapy is continued with minimal doses or the treatment period is shortened. Against the background of treatment, it is recommended to monitor liver function. You can not assign without exemption from work to persons whose professional activities require rapid physical and mental reactions.
- Use of Clomid during pregnancy and lactation
- Contraindicated in pregnancy.
- The category of action on the fetus according to the FDA is X
- Symptoms: nausea, vomiting, hot flashes, visual disturbances, abdominal pain.
- Treatment: symptomatic therapy.
- It is compatible with gonadotropin preparations.
Side effects of Clomid
- From the nervous system and sensory organs: headache, dizziness, depression, increased fatigue, anxiety, insomnia, slowing down the speed of mental and motor reactions, visual impairment.
- From the digestive tract: nausea, vomiting, gastralgia, flatulence, diarrhea.
- From the genitourinary system: cystic ovarian enlargement, dysmenorrhea, pollakiuria, polyuria, multiple pregnancy.
- Other: hot flashes, weight gain, pain in the lower abdomen, chest, testicles (in men), hyperthermia, reversible hair loss, allergic skin reactions
Hypersensitivity, severe hepatic and / or renal insufficiency, uterine bleeding of unknown etiology, ovarian cyst, tumor or insufficiency of pituitary function, pregnancy (including suspicion of it)
Indications for the use of Clomid
Anovulatory infertility (ovulation induction), dysfunctional uterine bleeding, amenorrhea (dysgonadotropic form, secondary, postcontraceptive), galactorrhea (against the background of a pituitary tumor), polycystic ovaries (Stein — Leventhal syndrome), Chiari-Frommel syndrome, androgen insufficiency, oligospermia, for the diagnosis of disorders of the gonadotropic function of the pituitary gland.
Pharmacological action-antiestrogenic. Binds estrogen receptors in the hypothalamus and ovaries. When taken orally, it is well absorbed from the gastrointestinal tract. It is metabolized in the liver. It is excreted with bile, undergoes enterohepatic recirculation. It is excreted from the body with feces. T1/2 is 5-7 days. In small doses, it increases the secretion of gonadotropins (prolactin, FSH and LH), stimulates ovulation. With a low content of endogenous estrogens in the body, it has a moderate estrogenic effect, with a high level — anti-estrogenic. By reducing the level of circulating estrogens, it promotes the secretion of gonadotropins. In large doses, it inhibits the secretion of gonadotropins. It does not have gestagenic and androgenic activity.