Anastrozole

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Anastrozole is an antitumor agent that inhibits the synthesis of estrogens. It inhibits the activity of aromatase, blocks the transformation of androstendon into estradiol. The drug has a positive effect in the treatment of estrogen-dependent tumors during postmenopause. Progestagenic, estrogenic and androgenic activity were not observed.

ANASTROZOLE DESCRIPTION

Powerful, highly selective non-steroidal flavor inhibitor. On women with breast cancer, has a therapeutic effect by reducing the level of estradiol. Women taking anastrozole in a dose of 1 mg, reduce the level of estradiol by 80%. When taken up to 10 mg per day does not affect the secretion of cortisol and aldosterone, ie, no need for the introduction of substitution corticosteroid therapy.

Anastrozole is used for:

  • Treatment of estrogen-dependent breast cancer in the postmenopause period;
  • Treatment of common breast cancer in the postmenopause period;
  • Adjuvant therapy of breast cancer in the period of postmenopause, in the early stages, after tamoxifen treatment for 2-3 years.

The active ingredient is anastrozole; one tablet contains 1 mg; auxiliary components: dye FD & C yellow #5, crosspovidone, magnesium stearate, povidone, lactose. By pharmacological group refers to hormone antagonists and similar means. Available in blisters of 20 tablets, one package contains 3 blisters. The tablets are flat, the color - yellow, square shape, on the surface of the tablets may be marbled.

The action of Anastrozole

Absorbed in a short period of time, when receiving on an empty stomach within two hours, the maximum concentration in the blood is reached. It is concluded rather slowly, the half-life is 40-50 hours. If applied on a full stomach, the absorption rate slows down. The dependence of pharmacokinetic parameters on the dosage or time of intake has not been studied. The effect of anastrozole does not depend on the age of women in postmenopause. The concentration of anastrozole in the blood reaches equilibrium approximately one week after the start of administration. In 72 hours after taking, 10% of the anastrozole is excreted in the urine and 60% is excreted as metabolites.

How to take Anastrozole

It is recommended to take 1 mg per day. The course of treatment is selected individually.

Contraindications for taking Anastrozol:

  • Hypersensitivity to the components of the drug;
  • Treatment with tamoxifenom;
  • Lactation period;
  • Horse failure;
  • Expressed or moderate liver failure;
  • Pregnancy;
  • Age up to 18 years;
  • Treatment with estrogen-containing medications.

PCT

Anastrozole is used as after the course therapy, for other drugs. PCT after taking Anastrozole is not carried out.

Side effects of taking Anastrozole

When using Anastrozol, such adverse reactions may occur:

  • Insomnia;
  • Bronchitis;
  • Anxiety;
  • Anemia;
  • Weight gain.